Prof. Dr. Martin Jäger

Hochschule Niederrhein. Dein Weg.



- Chemie und Biotechnologie B.Sc.

  • 5311 Angewandte Organische Analytik (V, 2 SWS; S, 1 SWS) (Teilmodul)
  • 5422 Wasseranalytik (V, 2 SWS; P, 2 SWS) (Teilmodul)
  • 5210 Instrumentelle Analytik Teil 1 und 2 (P, 2 SWS)

- Chemieingenieurwesen B.Eng.

  • 4210 Instrumentelle Analytik I für B.Eng. (P, 2 SWS)



- Chemie und Biotechnologie M.Sc.

  • 5703 Prozessanalytik (V, 2 SWS) (Teilmodul)
  • 5811 Labormanagement (S, 4 SWS)
  • 5900 Vertiefungspraktikum (P)
  • 5950 Projektmodul (P)
  • 5813 AKIA 1 (S, 3 SWS) (Teilmodul)
  • 5814 Umweltschutzanalytik (V, 2 SWS; Ü, 2 SWS; S, 2 SWS)
  • 5815 Hauptseminar Instrumentelle Analytik (S, 4 SWS)
  • 5822 Spektroskopische Methoden (S, 2 SWS) (Teilmodul)


- Chemieingenieurwesen M.Eng.

  • 4703 Prozessanalytik (V, 2 SWS) (Teilmodul)


Betreuung von kooperierenden Promotionen.

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   Berufliche Erfahrung

03/ 2013 bis heute       Professor für Instrumentelle Analytik
                                       Fachbereich Chemie, Hochschule Niederrhein

10/ 2011 bis 02/ 2013  Senior Scientist Analysis
                                       Analytical Research Center, DSM Nutritional Products Ltd.,
                                       Kaiseraugst, Schweiz

05/ 2007 bis 09/ 2011  Groupleader and Senior Scientist Structure Analysis
                                       Department of Medicinal Chemistry, Merck Research Laboratories, 
                                       vormals N.V. Organon, Oss, The Netherlands

04/ 2002 bis 04/ 2007  NMR Manager
                                       Drug Discovery, Intervet Innovation GmbH, Schwabenheim

01/ 2002 bis 03/ 2002  Wissenschaftlicher Angestellter
                                        Ruhr-Universität Bochum

12/ 1998 bis 11/ 2001  Research Associate
                                        Department of Chemistry, The University of Chicago, Chicago, IL, USA


03/ 1998                      Promotion
                                        Institut für Organische Chemie, Eberhard Karls Universität Tübingen

02/ 1995                      Diplom in Chemie
                                        Institut für Organische Chemie, Eberhard Karls Universität Tübingen

05/ 1988                      Abitur
                                        Albrecht Dürer Gymnasium, Hagen

   Stipendien und Auszeichnungen

12/1998 bis 05/ 2001  Alexander von Humboldt-Stipendiat (Feodor Lynen-Stipendium)
                                       The University of Chicago, Chicago, IL, USA

     1998                       Förderpreis der Fakultät für Chemie und Pharmazie der Universität Tübingen

03/ 1995 bis 02/ 1998  Kollegiat und Stipendiat des Graduiertenkollegs "Quantitative Analytik
                                        pharmazeutisch und biochemisch relevanter Substanzen"
                                        an der Universität Tübingen

10/1992 bis 04/ 1993   ERASMUS Stipendiat
                                        Université Claude Bernard Lyon I & Ecole Superieure de Chimie Industrielle
                                        de Lyon, Frankreich 


AG Jäger (2019)

Research interests

A brief German summary of the research interest can be found in the Mitteilungen 3/ 2019 (p. 91f)  der Fachgruppe Umweltchemie und Ökotoxikologie der GDCh. 

  • Pharmaceuticals in Waters 
  • Advanced Oxidation Processes for the removal of pharmaceuticals in waste water
  • Chemical kinetics of photo-induced degradation of pharmaceuticals
  • Environmental analysis using chromatography coupled to mass spectrometry

             For an impression: Watch this video 

The project Enz4Water combines the research efforts of several groups to develop enzymatic filters for use as a fourth purification stage in wastewater treatment plants.

  • Micro Process Analytical Technology
  • Spectroscopy for process analysis
  • Fieldable spectroscopy and mobile labs
  • NMR spectroscopy
  • Covariance NMR
    • To learn more about HeteroCovariance Spectroscopy and its application to Process Analytical Technology watch this video
    • To learn much more about Covariance NMR in general and its most recent applications wath the full video



ThermoFisher Scientific



This site is still under construction.


Voigt M., and Jaeger M., Structure and QSAR analysis of photoinduced transformation products of neonicotinoids from EU watchlist for ecotoxicological assessment, Sci. Total Environ., 2021, 751, 141634.

Voigt M., Wirtz A, Hoffmann-Jacobsen K.., and Jaeger M., Prior art for the development of a fourth purification stage in wastewater treatment plant for the elimination of anthropogenic micropollutants-a short-review, AIMS Environ. Sci., 2020, 7, 69–98.

Voigt M., Hentschel B., Theiss N., Savelsberg C., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity. Clean. Technol. 2020, 2, 74-90.

Legner R., Voigt M., Wirtz A., Friesen A., Haefner S., and Jaeger M. Using Compact Proton Nuclear Magnetic Resonance at 80 MHz and Vibrational Spectroscopies and Data Fusion for Research Octane Number and Gasoline Additive Determination, Energy & Fuels 2020, 34, 103-110.

Voigt M., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Determination of minimum inhibitory concentration and half maximal inhibitory concentration of antibiotics and their degradation products to assess the eco-toxicological potential. Tox. Env. Chem. 2019, 101, 315-338.

Legner R., Wirtz A., Koza T, Tetzlaff T., Nickisch-Hartfiel A., and Jaeger M., Application of green analytical chemistry to a green chemistry process: Magnetic resonance and Raman spectroscopic process monitoring of continuous ethanolic fermentation. Biotechnology and Bioengineering. 2019, 116, 2874-2883. (open access)

Schmitz C., Yang P., Guelz A, Glaeser M, Horst J, Jaeger M., and Strehmel B., New High‐Power LEDs Open Photochemistry for Near‐Infrared‐Sensitized Radical and Cationic Photopolymerization. Angew. Chem. Int. Ed. 2019, 58, 4400-4404.

Voigt M., Legner R., Haefner S., Friesen A., Wirtz A., and Jaeger M., Using fieldable spectrometers and chemometric methods to determine RON of gasoline from petrol stations: A comparison of low-field 1H NMR@80 MHz, handheld RAMAN and benchtop NIR. Fuel. 2019, 236, 829-835.

Voigt M., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Elimination of macrolides in water bodies using photochemical oxidation. AIMS Environ. Sci. 2018, 5, 372-388.

Legner R., Wirtz A., and Jaeger M., Using Compact 1H NMR, NIR and Raman Spectroscopy Combined with Multivariate Data Analysis to Monitor a Biocatalyzed Reaction in a Microreaction System, J. Spectrosc. 2018, 2018, 11 pages. (open access)

Wunschik D.S., Ingenbosch K.N., Zaehres M., Horst J., Mayer C., Jaeger M., Strehmel V., Dornbusch M., and Hoffmann-Jacobsen K., Biocatalytic and solvent-free synthesis of a bio-based biscyclocarbonate, Green Chemistry. 2018, 20, 4738-4745.

Werres T., Leonhardt J., Jaeger M., Teutenberg, T., Critical Comparison of Liquid Chromatography Coupled to Mass Spectrometry and Three Different Ion Mobility Spectrometry Systems on Their Separation Capability for Small Isomeric Compounds, Chromatographia. 2019, 82, 251-260.

Voigt M., Savelsberg C., and Jaeger M., Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation. J. Vis. Exp. 2018, 138, e57434. (open access and video)

Reinders L., Klassen M.D, Jaeger M., Teutenberg T., and Tuerk J., Development of an analytical method to assess the occupational health risk of therapeutic monoclonal antibodies using LC-HRMS. Anal. Bioanal. Chem. 2018, 410, 2829-2836.

Jaeger M. and Legner R., Homo- and heterocovariance NMR spectroscopy and applications to process analyticyl technology. In Spectroscopic Analyses - Developments and Applications, Zafar F. (ed.), InTech, 2017.

Voigt M., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Photoinduced degradation of sulfonamides, kinetic, and structural characterization of transformation products and assessment of environmental toxicity. Tox. Env. Chem. 2017, 99, 1304-1327.

Voigt M., Gold A., Blaesing C., Hoelscher T., and Jaeger M., Murky Waters. The Analytical Scientist. 2017, 0217, 36-41.

Hetzel T., Blaesing C., Jaeger M., Teutenberg T., and Schmidt T.C., Characterization of peak capacity of microbore liquid chromatography columns using gradient kinetic plots. J. Chrom. A. 2017, 1485, 62-69.

Voigt M., and Jaeger M., On the photodegradation of azithromycin, erythromycin, and tylosin and their transformation products - A kinetic study. Sustainable Chemistry & Pharmacy. 2017, 5, 131-140.

Voigt M., Savelsberg C., and Jaeger M., Photodegradation of the antibiotic spiramycin studied by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry. Tox. Env. Chem. 2017, 99, 624-640.

Jaeger M., Aspers R.L.E.G. and Voigt M. (2017) Covariance NMR. In: Lindon, J.C., Tranter, G.E., and Koppenaal, D.W. (eds.) The Encyclopedia of Spectroscopy and Spectrometry, 3rd edition vol. 1, pp. 396-400.

Legner R., Friesen A., Voigt M., Horst J., and Jaeger M., Automation of the picoSpin 80 1H NMR benchtop spectrometer for high-throughput determination of the research octane number of fuels. thermoscientific application note 2016, AN52906.

Legner, R., S. Haefner, M. Voigt, J. Horst, B. Eichel, P. Naderwitz, and M. Jaeger, Micro Process Analytical Technologies. G.I.T. Laboratory Journal 2016, 3-4, 38-40; Mikro - Prozess - Analytik. GIT - Labor-Fachzeitschrift 2015, 12, 32-34.

Wijmenga, S.S. and M. Jaeger, 19F-Detected NMR of Multifluorinated Compounds. eMagRes. 2015, 31-36.

Jaeger, M., and R.L.E.G. Aspers, Covariance NMR and Small Molecule Applications. Annu. Rep. NMR Spectrosc. 2014, 83, 271-349.

Aspers, R.L.E.G., K.A.M. Ampt, P. Dvortsak, M. Jaeger, and S.S Wijmenga, Fluorine detected 2D NMR experiments for the practical determination of size and sign of homonuclear F-F and heteronuclear C-F multiple bond J-coupling constants in multiple fluorinated compounds. J. Magn. Reson. 2013, 231, 79-89.

Jaeger, M., and R.L.E.G. Aspers, Steroids and NMR. Annu. Rep. NMR Spectrosc. 2012, 77, 115-258.

Ampt, K.A.M., R.L.E.G. Aspers, P. Dvortsak, R.M. van der Werf, S.S. Wijmenga, and M. Jaeger, Determination of size and sign of hetero-nuclear coupling constants from 2D 19F-13C correlation spectra. J. Magn. Reson. 2012, 215, 27-33.

Kaptein A., A. Oubrie, E. de Zwart, N. Hoogenboom, J. de Wit, B. van de Kar, M. van Hoek, G. Vogel, V. de Kimpe, C. Schultz-Fademrecht, J. Borsboom, M. van Zeeland, J. Versteegh, B. Kazemier, J. de Roos, F. Wijnands, J. Dulos, M. Jaeger, P. Leandro-Garcia,  T. Barf, Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 Inhibitors. Biorg. Med. Chem. Lett. 2011, 21, 3823-3827.

Aspers, R.L.E.G., P.E.T.J. Geutjes, M. Honing, and M. Jaeger, Using indirect covariance processing for structure elucidation of small molecules in cases of spectral crowding. Magn. Reson. Chem. 2011, 49, 425-436.

Ampt, K.A.M., R.L.E.G. Aspers, M. Jaeger, P.E.T.J. Geutjes, M. Honing, and S.S. Wijmenga, Application of Fluorine NMR for structure identification of steroids. Magn. Reson. Chem. 2011, 49, 221-230.

Jaeger, M., B. Rothacker, T. Ilg, Saturation transfer differenece NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Biochem. Biophys. Res. Commun. 2008, 372, 400-406.

Chassaing, C., M. Berger, A. Heckeroth, T. Ilg, M. Jaeger, C. Kern, K. Schmid, M. Uphoff, Highly water-soluble prodrugs of anthelmintic benzimidazole carbamates: Synthesis, pharmacodynamics, and pharmacokinetics. J. Med. Chem. 2008, 51, 1111-1114.

Kolano, C., G. Bucher, H.H. Wenk, M. Jaeger, O. Schade, and W. Sander, Photochemistry of 9-fluorenone oxime phenylglyoxalate: a combined TRIR, TREPR and ab initio study. J. Phys. Org. Chem. 2004, 17, 207-214.

Ostafin, A.E., N.S. Ponomarenko, J.A. Popova, M. Jaeger, E.J. Bylina, and J.R. Norris, Jr., Characterization of expressed pigmented core light harvesting complex (LH 1) in a reaction center deficient mutant of Blastochloris viridis. Photosynth. Res., 2003, 77, 53-68.

Kolbasov, D., N. Srivatsan, N. Ponomarenko, M. Jaeger, and J.R. Norris, Jr., Modeling Charge Transfer in Oxidized Bacterial Antenna Complexes. J. Phys. Chem. B, 2003, 107, 2386-2393.

Jaeger, M., and J.R. Norris, Jr., Computation of time-resolved EPR spectra of systems exhibiting electron spin polarization complicated by magnetization transfer. J. Phys. Chem. A, 2002, 106, 3659-3664.

Jager, M., B.C. Yu, and J.R. Norris, Jr., Exploring Complex CIDEP of p-Benzosemiquinones with Time-Resolved CW-EPR. Mol. Phys., 2002, 100, 1323-1331.

Jager, M. and J.R. Norris, Jr., A Time-resolved EPR study of the Electron-spin-polarization Pathways of p-Benzoquinone. J. Magn. Reson., 2001, 150, 26-34.

Jaeger, M., P. Schuler, H.B. Stegmann, and A. Rockenbauer, Molecular recognition analyzed by observing intramolecular interconversion with EPR spectroscopy. Z. Naturforsch., B: Chem. Sci., 1998. 53(12), 1511-1519.

Jager, M., P. Schuler, H.B. Stegmann, and A. Rockenbauer, Molecular recognition. II Discrimination of specific and non-specific intermolecular interactions by means of magnetic resonance spectroscopy. Magn. Reson. Chem., 1998. 36(3), 205-210.

Jager, M. and H.B. Stegmann, Stereoelectronic effect at nitrogen in 2,6-di-tert-butyl-4-(N,N-disubstituted aminomethyl)phenoxyl radicals. J. Chem. Soc., Perkin Trans. 2, 1998(3), 697-700.

Jaeger, M. and H.B. Stegmann, Molecular recognition analyzed by EPR, ENDOR, and NMR spectroscopy. Angew. Chem. 1996. 108: p. 1943-1946; Angew. Chem., Int. Ed. Engl., 1996. 35(16), 1815-1818.



Jaeger M. and Aspers R.L.E.G. Nuclear Magnetic Resonance of Steroids. In: Williams, A.J., Martin, G.E.,  and Rovnyak, D. (eds.) Modern NMR Approaches to the Structure Elucidation of Natural Products: Volume 2: Data Acquisition and Applications to Compound Classes.  pp. 275-314. The Royal Society of Chemistry,, 2017. DOI:10.1039/9781849734684

Mecke, R., H.H. Jäger, and M. Jäger. Aroxyl Radicals in “Landolt-Börnstein/New Series. Numerical Data and Functional Relationships in Science and Technology”, New Series, Vol. II/ 26. c, Springer-Verlag, Berlin, Heidelberg, New York 2004. 

Inhouse Arbeiten

Projekt-/Bachelor-/Masterprojekt- und Masterarbeiten 


Tiebe, S.; Untersuchung von Fließgewässern hinsichtlich der Anwesenheit und Konzentration unterschiedlicher Pharmazeutika mittels Hochleistungsflüssigkeitschromatographie gekoppelt mit Elektrospray-Ionisation-Quadrupol-Time-Of-Flight-Massenspektrometrie, B.Sc.

Sack, M.; Über die Entwicklung eines einfachen und robusten analytischen Tests zum vor-Ort- Nachweis von „Badesalzen“, B.Sc.

Sandmann, P.; Ökotoxizität ausgewählter chemischer Substanzen, B.Sc.


Schöttl, J.; Entwicklung einer SERS-Methode zum Nachweis von Imidacloprid auf Polylactidgewebe mithilfe von Goldnanopartikeln, B.Sc.

Mahler, L., Anwendung prozessanalytischer Methoden auf mikrobiologische und chemische Reaktionen, M.Sc.

Bartels, I., UVC-Degradation und Ozonung ausgewählter Schadstoffe in Abwässern und Analyse ihrer Abbauprodukte mittels HPLC-ESI-Q-TOF-MS, M.Sc.


Lamers, D., Optimierung von SERS-Untersuchungen von Pestiziden in Lösung und auf verschiedenen Substraten, B.Sc.

Votel, L., Untersuchung des photoinduzierten Abbaus von Iod-Kontrastmitteln und Metoprolol mittels HPLC-MS, B.Sc.


Servatius, C., Untersuchung des Carotinoidgehaltes von Pflanzenteilen mittels mobiler Raman-Spektroskopie während des Reifeprozesses, M.Sc.

Arndt, S., Degradation von Metoprolol und Sulfamethoxazol in Wasser unter Laborbedingungen durch Elektrolyse und Photolyse, B.Sc.

Hentschel, B., Comparison of photo-induced degradation and mineralization of five fluoroquinolones in ultrapure water and surface water using HPLC-ESI-qTOF-MS and TOC, B.Sc.

Theiß, N., Photo-induzierte Degradation von Antiobiotika mittels UV-A Licht, B.Sc.


Koza, T., Anwendung von Green Chemistry und Process Analytical Technology im Mikroreaktionssystem zur Synthese einer Biomasse-basierten Plattformchemikalie, M.Sc.

Hermsen, A., Surface-Enhanced Raman Spectroscopy: Entwicklung eines Nanopartikel basierten Substrates und Anwendung auf Neonicotinoid-Pestizide, M.Sc.

Tetzlaff, T., Mikro-Prozess-Analytik 2.0: Optimierung eines katalytischen Prozesses der Grünen Chemie, B.Sc.

Klein, J., Der Reifegradindex für Tomaten: Reifegradbestimmung von Tomaten verschiedener Reifestadien mittels portabler Ramanspektroskopie und Betrachtung des Nachreifungsprozesses nach der Ernte, B.Sc.

Wirtz, A., Mikro-Prozess-Analytik einer Fermentation und Isoamylacetatherstellung, B.Sc.

Bartels, I., Photo-induzierte Degradation und Evaluierung potentieller Umwelttoxizität ausgewählter Antibiotika und deren Photoprodukte anhand von MHK, B.Sc.

Savelsberg, C.,Untersuchungen von Pharmazeutika in Oberflächengewässern und Abwässern mittels hochauflösender HPLC-MS und MSn, B.Sc.


Friesen, A., Mikro-Prozess-Analytik mit spektroskopischen Methoden, M.Sc.

Barbarino, F., Optimierung der Wasserdampfdestillation ausgewählter Phenole in Klärwerken und Auswertung mit GC-MS und Vergleich mit der DIN-Norm 38409 "Phenol-Index", M.Sc.

Hermsen, A., Untersuchung von Photodegradanten von Pharmazeutika bezüglich ihrer Hemmung gegen Pseudomonas putida und Pseudomonas fluorescens, B.Sc.


Legner, R., Mikro-Prozess-Analytik: Eine Kombination von Mikroreaktionstechnologie mit low-field NMR, M.Sc.

Häfner, S., Mikro-Prozess-Analytik: Eine Kombination von Mikroreaktionstechnologie mit Schwingungsspektroskopie, M.Sc.

Strube, M., Analysis of environmental relevant compounds with electrospray ionization trapped ion mobility spectrometry - mass spectrometry (ESI-TIMS-MS), M.Sc.

Ridene, L., Methodenentwicklung zum Nachweis von Pharmazeutika und endokrin wirksamen Substanzen im Krefelder Abswasser mittels LC-MS - Vergleich von LC-Ionenfalle-MS und LC-QTOF-MS, B.Sc.


Mitglieder der Arbeitsgruppe Martin Jäger

Indra Bartels, M.Sc.
Doktorandin / Betreuer an der HN: Prof. Dr. Martin Jäger
Lukas Mahler, M.Sc.
Doktorand / Betreuer an der HN: Prof. Dr. Martin Jäger
Dr. Melanie Voigt
Wissenschaftliche Mitarbeiterin Organische Spurenanalytik
Andrea Hermsen, M.Sc.
Doktorandin / Betreuer an der HN: Prof. Dr. Martin Jäger